Cardioprotection by Adiponectin
نویسندگان
چکیده
منابع مشابه
Adiponectin: an indispensable molecule in rosiglitazone cardioprotection following myocardial infarction.
RATIONALE Patients treated with peroxisome proliferator-activated receptor (PPAR)-gamma agonist manifest favorable metabolic profiles associated with increased plasma adiponectin (APN). However, whether increased APN production as a result of PPAR-gamma agonist treatment is an epiphenomenon or is causatively related to the cardioprotective actions of PPAR-gamma remains unknown. OBJECTIVE To d...
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The circulating, adipocyte-secreted hormone adiponectin (APN) exerts protective effects on the heart under stress conditions. The receptors binding APN to cardiac tissue, however, have remained elusive. Here, we report that the glycosyl phosphatidylinositol–anchored cell surface glycoprotein T-cadherin (encoded by Cdh13) protects against cardiac stress through its association with APN in mice. ...
متن کاملAdiponectin mediates cardioprotection in oxidative stress-induced cardiac myocyte remodeling.
Reactive oxygen species (ROS) induce matrix metalloproteinase (MMP) activity that mediates hypertrophy and cardiac remodeling. Adiponectin (APN), an adipokine, modulates cardiac hypertrophy, but it is unknown if APN inhibits ROS-induced cardiomyocyte remodeling. We tested the hypothesis that APN ameliorates ROS-induced cardiomyocyte remodeling and investigated the mechanisms involved. Cultured ...
متن کاملEssential role of caveolin-3 in adiponectin signalsome formation and adiponectin cardioprotection.
OBJECTIVE Adiponectin (APN) system malfunction is causatively related to increased cardiovascular morbidity/mortality in diabetic patients. The aim of the current study was to investigate molecular mechanisms responsible for APN transmembrane signaling and cardioprotection. METHODS AND RESULTS Compared with wild-type mice, caveolin-3 knockout (Cav-3KO) mice exhibited modestly increased myocar...
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Perioperative myocardial infarction is a leading cause of morbidity and mortality after major non-cardiac surgery. Pharmacological agents such as beta-blockers may reduce the risk but are associated with side-effects and may be contra-indicated in some patients. Basic scientific experiments and preliminary clinical trials in humans suggest that remote ischaemic preconditioning (RIPC), where bri...
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ژورنال
عنوان ژورنال: Trends in Cardiovascular Medicine
سال: 2006
ISSN: 1050-1738
DOI: 10.1016/j.tcm.2006.03.001